Inflammatory and Autoimmune Diseases
An Introduction to Autoimmune diseases
Autoimmunity and deregulation of the immune system contribute to many skin diseases, including systemic sclerosis, dermatomyositis, psoriasis, vitiligo, alopecia areata and lichen sclerosus; inflammatory diseases such as hidradenitis suppurativa, allergic contact dermatitis and atopic eczema; and autoimmune blistering diseases, including pemphigus vulgaris, bullous pemphigoid, epidermolysis bullosa acquisita and dermatitis herpetiformis. Established treatments for autoimmune diseases include systemic corticosteroids and immunosuppressive therapies, while new therapies in development include biologic therapies targeting cytokines such as tumour necrosis factor alpha and interleukins (ILs) IL-23 and IL-17; enzymes such as Janus kinase-1 (JAK-1); and the regulatory protein-retinoic acid receptor-related-orphan-receptor-gamma t (RORγt).
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New 52-week REZOLVE-AD data showed durable responses with monthly and quarterly rezpegaldesleukin (REZPEG) maintenance dosing in atopic dermatitis. Prof. Thomas Bieber discusses the findings and the potential for long-term remission and disease modification, highlighting the further evidence needed to explore these goals.
How does bimekizumab perform in everyday clinical practice? An Italian multicenter study reported improvements in disease activity, pain, and quality of life in people with hidradenitis suppurativa, with no unexpected safety signals. Dr Mario Valenti shares the findings and his perspective with touchDERMATOLOGY.
Encouraging findings from JAKPPPOT support the feasibility of a definitive randomized controlled trial of Janus kinase inhibitors in palmoplantar pustulosis and provide an exploratory estimate of treatment effect. We spoke with Dr David Gleeson about the results presented at EADV 2026 and their implications for future research.
Dr Maria-Angeliki Gkini explores the growing role of psychodermatology in supporting patients’ wider needs, alongside emerging technologies and approaches that could shape the future management of psoriatic disease.
We are delighted to announce Dr Dennis Niebel as a touchDERMATOLOGY Future Leader 2026, selected for his contributions to immune-mediated skin disorders and sustainable dermatology. Germany-based Dr Dennis Niebel is a Lecturer and Consultant Dermatologist at the University of Cologne (Cologne, ...
We are delighted to announce Dr Dimitri Luz as a touchDERMATOLOGY Future Leader 2026. Dr Luz is helping to advance immune-mediated dermatology through his work in clinical care, research, and medical education. A Brazilian-trained dermatologist now based in Perth, Australia, his ...
We are delighted to introduce Dr Olufolakemi Cole-Adeife as a touchDERMATOLOGY Future Leader 2026. Dr Cole-Adeife is a Consultant Physician, Dermatologist and Venereologist at Lagos State University Teaching Hospital (LASUTH) and a Lecturer at Lagos State University College of Medicine in ...
We are delighted to introduce Dr Benjamin Ungar as a touchDERMATOLOGY Future Leader 2026. Dr Ungar is an Assistant Professor of Dermatology at the Icahn School of Medicine at Mount Sinai in New York, USA, where he is Director of the ...
We are delighted to welcome Dr Giovanni Damiani as a touchDERMATOLOGY Future Leader 2026. Giovanni Damiani, MD, PhD, MSc, is Associate Professor of Dermatology and Venereology at the University of Milan (Milan, Italy) and Clinical Professor at Case Western Reserve University (...
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