A-STAR is the The UK-Irish Atopic Eczema Systemic Therapy Register, an observational study investigating short and long-term safety and efficacy of systemic immuno-modulators for people with atopic dermatitis. The register also assesses the ‘real life’ cost of eczema treatments, comparing therapeutic costs with efficacy. touchDERMATOLOGY caught up with Prof. Carsten Flohr (Guy’s & St Thomas’ NHS Foundation Trust, London, UK) to discuss participants, treatments and outcome measures of the A-STAR register and the comparative efficacy and safety findings. 'Comparing the treatment effectiveness and safety of dupilumab and methotrexate in paediatric and adult atopic dermatitis: results from the A-STAR register' was presented at EADV 2023, Berlin, 11-14 October 2023 #EADVCongress. Questions What impact has dupilumab had on the treatment paradigm for atopic dermatitis since its approval? (0:12) Could you give us a brief overview of the participants, treatments and outcome measures of the A-STAR register? (0:42) What were the aims and design of your analysis of the A-STAR register? (1:09) What were the comparative efficacy and safety findings of your study? (1:57) What were the key take home messages from your study? (2:50) Disclosures: Carsten Flohr has nothing to disclose in relation to this video interview. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones and Katey Gabrysch. Filmed in coverage of the EADV Annual Meeting. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

BE HEARD I and II, were phase 3 clinical trials that investigated the efficacy and safety of bimekizumab for the treatment of hidradenitis suppurativa (HS). In this interview, we were delighted to speak with Prof. Christos C. Zouboulis (Brandenburg Medical School Theodor Fontane, Neuruppin, Germany) to discuss the rationale for investigating bimekizumab in HS, the aims, methodology and findings from his analysis of BE HEARD I and II, and the next steps for the development of bimekizumab. The abstract 'Bimekizumab efficacy and safety in patients with moderate to severe hidradenitis suppurativa: Analysis of pooled data from BE HEARD I and II phase 3, randomised, double-blind, placebo-controlled, multicentre studies' (Abstract N°: 3262) was presented at EADV 2023, Berlin, 11-14 October 2023 #EADVCongress. Questions What are the latest updates to the treatment guidelines for hidradenitis suppurativa (HS)? What is the mechanism of action and rationale for investigating bimekizumab for the treatment of HS? What were the aims and methodology of your pooled analysis of BE HEARD I and II? What were the efficacy and safety findings from your analysis? What will be the next steps in the clinical development of bimekizumab in this indication? Disclosures: Christos C. Zouboulis has nothing to disclose in relation to this interview. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones and Katey Gabrysch. Filmed in coverage of the EADV Annual Meeting. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

There are a number of cutaneous manifestations associated with lupus erythematosus, pushing forward for innovative approaches and emerging investigational therapeutics in clinical trials. touchDERMATOLOGY were delighted to speak with Dr. Victoria P. Werth (University Perelman School of Medicine, Philadelphia, PA, USA) to discuss the key developments, novel insights and future directions in the field of lupus erythematosus. This information is provided solely by Touch Medical Media and is independent of any sponsorship or affiliation with the European Academy of Dermatology & Venereology (EADV). The presentation 'New insights and therapeutic approaches in Lupus Erythematosus' (Presentation ID PLB-03) was presented at EADV 2023, Berlin, 11-14 October 2023 #EADVCongress. Questions Could you tell us a little about lupus erythematosus and the unmet needs in its treatment? (0:18) What cutaneous manifestations are associated with lupus erythematosus? (1:45) What novel therapeutic approaches are changing the way that lupus is treated? (2:16) What investigational therapeutics show promise for lupus erythematosus in clinical trials? (3:10) What are the key developments and future directions in the field of lupus erythematosus? (5:00) Disclosures: Victoria Werth has received grants from Celgene, Amgen, Janssen, Biogen, Gilead, Viela; Horizon therapeutics, and Ventus; and is/has been a consultant (and received honorarium) for Astra-Zeneca, Pfizer, Biogen, Celgene, Resolve, Janssen, Gilead, Lilly, BMS, Nektar, Abbvie, Viela, GSK, EMD Serona, Sanofi, Anaptysbio, Amgen, Merck Kyowa Kirin, Rome Therapeutics, and Xencor; and is on the Lupus Foundation of America advisory board. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones and Katey Gabrysch. Filmed in coverage of the EADV Annual Meeting. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

OLYMPIA 2 (NCT04501679) was a phase 3, multicentre, double-blind study that investigated the IL-31 inhibitor nemolizumab for the treatment of prurigo nodularis in adults. touchDERMATOLOGY were delighted to speak with Prof. Adam Reich (University of Medicine, Wroclaw, Poland) around his analysis of OLYMPIA 2, looking at improvements in pain and patient reported outcomes. The abstract ‘Nemolizumab modulates prurigo nodularis-associated skin pain and markedly improves patient reported outcomes in patients with moderate-to-severe prurigo nodularis in a phase 3 study (OLYMPIA 2).' (Abstract N°: 4147) was presented at EADV 2023, Berlin, 11-14 October 2023 #EADVCongress. Questions What is the mechanism of action and rationale for investigating nemolizumab in prurigo nodularis? (0:18) Could you describe the aims and design of the phase 3 OLYMPIA 2 study, and how well the key endpoints were met? (0:50) What additional outcomes were investigated in your analysis of OLYMPIA 2 and how well were they met? (1:29) What will be the next steps in the clinical development of  nemolizumab? (2:05) Disclosures: Adam Reich discloses receiving grant/research support from Abbvie, Anaptys, BMS, Dice, Eli Lilly, Galderma, Incyte, Jannsen, Medac, Novartis, Pfizer, Regeneron, Trevi Therapeutics, and UCB; serving on advisory boards for Abbvie, Galderma, Leo Pharma, Sanofi, Novartis, and Eli Lilly. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones and Katey Gabrysch. Filmed in coverage of the EADV Annual Meeting. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

Janus kinase inhibitors (JAKis) have transformed the landscape of dermatological therapy over the last 2 years, with six United States Food and Drug Administration approvals and further clinical trials in progress.1 JAKis have proven highly efficacious in dermatological diseases, by blocking the JAK-signal transducer and activator of transcription (STAT) signalling pathway involved in numerous inflammatory […]

The pathogenesis of cutaneous granulomatous disorders is incompletely understood and many unmet needs remain in the treatment paradigm.1 These disorders can be categorized into two main groups: those caused by infections and those associated with inflammatory skin conditions, among the most prevalent inflammatory disorders are granuloma annulare (GA) and cutaneous sarcoidosis (CS).1 The presentation of […]

Chronic spontaneous urticaria (CSU), a common and distressing skin condition driven by mast cells, is typically managed with a stepwise approach using second-generation H1-antihistamines, omalizumab and cyclosporine, as recommended by international guidelines. However, many patients with CSU do not respond optimally to this standardized treatment, likely due to the diverse underlying mechanisms involved. As a […]