Psoriasis
An Introduction to Psoriasis
Psoriasis is a common, chronic, inflammatory skin disease that can also affect the joints. Management involves topical and systemic medication and phototherapy. In the past decade, increased understanding of the pathophysiology of autoimmune diseases has resulted in the development of systemic biologic therapies for moderate-to-severe disease, including inhibitors of tumour necrosis factor alpha and the interleukins (IL) IL-12, IL-23, and IL-17A. Topical medications, including corticosteroids, vitamin D analogues, calcineurin inhibitors and keratolytics, are the mainstay treatment for mild-to-moderate psoriasis. Other therapies recently approved for psoriasis include tapinarof, a topical aryl hydrocarbon receptor modulating agent, and deucravacitinib, an oral tyrosine kinase 2 inhibitor.
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