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Denver aad 2026
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Join us as leading experts discuss key data and perspectives from the late-breaking sessions at this year’s AAD meeting This March, experts from around the world gathered in Denver, Colorado, for the 2026 American Academy of Dermatology (AAD) Annual Meeting. This year’s meeting showcased a strong pipeline of innovation in inflammatory and immune-mediated skin diseases, […]

Molecular signatures of aging skin reveal potential anti-aging targets

Helen He
4 mins
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AAD 2026
Published Online: Apr 2nd 2026

TouchDERMATOLOGY coverage from AAD 2026:

“Aesthetic dermatology is shifting away from only treating the clinical signs of skin aging towards longevity-based approaches that aim to target the drivers of aging”

As interest continues to grow in better understanding the biology of skin aging, non-invasive tools such as tape stripping are opening up new possibilities for molecular research that may help identify strategies to slow skin aging and promote skin longevity.

In this Q&A, Dr Helen He (New York, NY, USA) discusses her latest study, which was presented as a late-breaking abstract at this year’s AAD Annual Meeting, and the insights it offers into the mechanisms of skin aging and future targeted interventions.

Q. What is tape stripping and why is it proving to be such a useful tool in omics-based skin research?

Tape stripping is a method for collecting skin samples involving consecutive application of adhesives on the skin, providing a minimally invasive alternative to biopsies. Genetic material can then be extracted from tape strips for omics-based research. We have validated tape stripping in multiple studies, showing that they accurately capture key biomarkers of skin diseases, such as atopic dermatitis and psoriasis. Because tape strips are painless, carry virtually no risk of scarring, bleeding, or infection, and require very little material to run complex analyses, they will be game changing for skin aging and cosmetics research, especially for sampling skin from cosmetically sensitive areas like the face.

Q. What was the rationale for exploring the molecular signatures of healthy skin aging?

Aesthetic dermatology is shifting away from only treating the clinical signs of skin aging towards longevity-based approaches that aim to target the drivers of aging at the root cause, such as the molecular hallmarks of aging. By performing skin profiling to define the molecular signatures of healthy skin aging, we will have a much better scientific understanding of how the skin changes at the cellular and molecular level as it ages, and how senescence, inflammation, genomic instability, and other aging hallmarks interact in the skin. This will also allow us to discover new biomarkers of aging that could be potentially targeted through skincare, procedures, or even medications.

Q. Could you talk us through the study design, including its aims, methodology and the participant population involved?

We recruited 156 healthy volunteers with ages ranging 20 to 85 years old. Our study cohort was diverse with respect to both race and gender. In each subject, we took tape strips from the photoprotected inner arm and the photo-exposed face, followed by transcriptomic profiling with RNA-sequencing, where we measured the expression levels of over 20,000 genes. Our objective is to characterize the molecular changes that occur with intrinsic and extrinsic skin aging and define unique differences across race and gender, with the goal of developing individualized therapeutic strategies for anti-aging and promoting longevity.

Q. What were the key findings to emerge from the research, and what do these reveal about potential new interventional or anti-aging targets?

We identified distinct molecular signatures of intrinsic and extrinsic aging across all hallmarks of aging. Photoaged skin uniquely showed up-regulation of melanogenesis, with early activation of UV response genes starting at age 40 years, while skin barrier defects were more pronounced and showed up earlier in photoprotected skin. This points to the importance of moisturizing to support skin barrier function on the body, and photoprotection and antioxidant treatment on the face. Inflammaging patterns were different across racial groups. For example, Asian participants showed early immune activation at age 40-60 years followed by attenuation of immune activity at older age, while white skin demonstrated progressive age-associated increases in many immune markers. Females over age 60 years showed enrichment of androgenization pathways that correlated with the degree of immune and barrier dysfunction. These findings suggest new biomarkers of aging and potential interventional targets against inflammaging, oxidative stress, and senescence.

Q. How might these findings now be translated into targeted interventions to support skin aging and longevity, and what are the next steps for future investigations?

By defining biomarkers of intrinsic and extrinsic aging across different hallmarks of aging and elucidating their interactions specifically in the skin, we have identified potential anti-aging targets that can be further investigated and validated in future studies. We hope to expand this study and sample size to work towards the goal of individualized biomarkers and personalized regimens that promote skin longevity.

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Abstract: He H. Molecular signatures of healthy skin aging highlight potential interventional anti-aging targets using tape strips. S023 Late-Breaking Research: Session 1. AAD 2026, March 27-21,  Denver, CO, USA.

Cite: He H. Molecular signatures of aging skin reveal potential anti-aging targets. touchDERMATOLOGY. 02 April 2026.

Editor: Gina Furinval.

This content has been developed independently by Touch Medical Media for touchDERMATOLOGY. It is not affiliated with the American Academy of Dermatology (AAD). Views expressed are the speaker’s own and do not necessarily reflect the views of Touch Medical Media.

Disclosures: Helen He discloses consulting for Abbvie, receiving grant/research support from Clinique and serving on advisory boards for L’Oreal.

About Dr Helen He

Dr Helen He is a board-certified dermatologist and Assistant Professor in the Kimberly and Eric J. Waldman Department of Dermatology at Mount Sinai. She serves as Director of Lasers and Cosmetic Surgery and co-directs the Mount Sinai–Clinique Healthy Skin Dermatology Center. Her clinical work spans medical and cosmetic dermatology, while her research focuses on inflammatory skin diseases and skin aging. Dr He earned her BS from MIT and MD from Mount Sinai, where she also completed her dermatology residency.

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