Hidradenitis suppurativa
Watch Time: 7 mins

Phase III SUNSHINE and SUNRISE trials investigating secukinumab in hidradenitis suppurativa: Afsaneh Alavi

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Published Online: Dec 5th 2023

The phase III SUNSHINE and SUNRISE were two identical, multicentre, randomized, placebo-controlled, double-blind phase 3 trials performed in 219 primary sites across 40 countries. With few therapeutic options available for patients with moderate-to-severe hidradenitis suppurativa (HS), Dr Afsaneh Alavi (Mayo Clinic College of Medicine, Rochester, MN, USA) joins touchDERMATOLOGY to discuss the limitations of current therapeutic options for HS, and the clinical utility of secukinumab in the treatment of dermatological diseases. Dr Afsaneh also delves into the two trials and their findings, aimed at assessing the efficacy of secukinumab in patients with moderate-to-severe HS.


  1. What are the limitations of current therapeutic options for hidradenitis suppurativa (HS)? (0:27)
  2. What is already known about the clinical utility of secukinumab in the treatment of dermatological diseases? (2:29)
  3. Could you describe the rationale and methodology of the Phase III SUNSHINE and SUNRISE trials? (3:58)
  4. What were the efficacy and safety findings from these studies? (4:37)
  5. Following EU approval, what do you believe will be the place of secukinumab in the treatment paradigm for HS? (6:21)

Disclosures: Dr Afsaneh Afsaneh has been a consultant for Abbvie, Almirall, BI, InflaRX, Incyte, Kymera, Janssen, Novartis, and UCB; is on the advisory board for BI, Incyte, Novartis, and UCB; and has received honoraria/honorarium from Abbvie, Almirall, BI, InflaRX, Incyte, Kymera, Janssen, Novartis, and UCB.

Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Katey Gabrysch.

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BE HEARD I and II phase 3 trials – pooled analysis of bimekizumab in hidradenitis suppurativa: Christos C. Zouboulis, EADV 2023
Watch Time: 4 mins

BE HEARD I and II, were phase 3 clinical trials that investigated the efficacy and safety of bimekizumab for the treatment of hidradenitis suppurativa (HS). In this interview, we were delighted to speak with Prof. Christos C. Zouboulis (Brandenburg Medical School Theodor Fontane, Neuruppin, Germany) to discuss the rationale for investigating bimekizumab in HS, the aims, methodology and findings from his analysis of BE HEARD I and II, and the next steps for the development of bimekizumab. The abstract 'Bimekizumab efficacy and safety in patients with moderate to severe hidradenitis suppurativa: Analysis of pooled data from BE HEARD I and II phase 3, randomised, double-blind, placebo-controlled, multicentre studies' (Abstract N°: 3262) was presented at EADV 2023, Berlin, 11-14 October 2023 #EADVCongress. Questions What are the latest updates to the treatment guidelines for hidradenitis suppurativa (HS)? What is the mechanism of action and rationale for investigating bimekizumab for the treatment of HS? What were the aims and methodology of your pooled analysis of BE HEARD I and II? What were the efficacy and safety findings from your analysis? What will be the next steps in the clinical development of bimekizumab in this indication? Disclosures: Christos C. Zouboulis has nothing to disclose in relation to this interview. Support: Interview and filming supported by Touch Medical Media Ltd. Interview conducted by Victoria Jones and Katey Gabrysch. Filmed in coverage of the EADV Annual Meeting. This content was developed by Touch Medical Media and is not affiliated with the  European Academy of Dermatology & Venereology  (EADV) or the congress. 

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